{"product_id":"mots-c","title":"MOTS-c","description":"\u003ch1\u003e\u003cspan\u003eMOTS-c – 10 mg\u003c\/span\u003e\u003c\/h1\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eAdvanced Mitochondrial-Derived Peptide | Cellular Energy \u0026amp; Metabolic Research\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eMOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a naturally occurring 16-amino-acid peptide encoded within mitochondrial DNA.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eUnlike many traditional peptides, MOTS-c originates from genetic information associated with mitochondria, the cellular structures responsible for much of the body's energy production.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eMOTS-c has attracted significant scientific interest for its involvement in cellular energy regulation, glucose metabolism, insulin sensitivity and responses to metabolic stress.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eIts distinctive biological activity has made it an emerging subject of research in mitochondrial science, metabolic health, exercise physiology and age-related cellular function.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3\u003e\u003cspan\u003eHow Does MOTS-c Work?\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cspan\u003ePreclinical research suggests that MOTS-c influences several important biological pathways:\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eMitochondrial \u0026amp; Cellular Energy Regulation:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e Investigated for its role in coordinating cellular metabolism and communication between mitochondria and the cell nucleus.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eAMPK Activation:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e Studied for its interactions with AMP-activated protein kinase (AMPK), a key regulator of cellular energy balance and metabolic signalling.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eGlucose Metabolism:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e Animal studies have examined its potential influence on glucose utilisation, insulin sensitivity and metabolic homeostasis.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eExercise \u0026amp; Muscle Research:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e Investigated for its relationship with skeletal muscle metabolism, exercise-induced signalling and physical performance in animal models.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eMetabolic Stress Response:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e Research suggests MOTS-c may influence cellular adaptation to metabolic challenges through changes in gene expression.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eAgeing \u0026amp; Cellular Function:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e Explored in preclinical studies investigating age-associated changes in metabolic regulation and physical capacity.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eOxidative Stress Pathways:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e Studied for its potential interactions with cellular antioxidant signalling and stress-response mechanisms.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan\u003eAlthough these findings are promising areas of scientific investigation, they are predominantly based on laboratory and animal studies rather than established human clinical outcomes.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3\u003e\u003cspan\u003eKey Research Areas\u003c\/span\u003e\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cspan\u003eMitochondrial function and cellular metabolism\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cspan\u003eAMPK activation and energy regulation\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cspan\u003eInsulin sensitivity and glucose metabolism\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cspan\u003eSkeletal muscle and exercise physiology\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cspan\u003eMetabolic stress and cellular adaptation\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cspan\u003eAge-associated metabolic changes\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cspan\u003eOxidative stress and antioxidant signalling\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cspan\u003eMitochondrial-to-nuclear communication\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cspan\u003eMetabolic homeostasis and energy balance\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003e\u003cspan\u003eProduct Information\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eProduct:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e MOTS-c\u003c\/span\u003e\u003cbr\u003e\u003cstrong\u003e\u003cspan\u003eStrength:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e 10 mg\u003c\/span\u003e\u003cbr\u003e\u003cstrong\u003e\u003cspan\u003eClassification:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e Mitochondrial-Derived Peptide\u003c\/span\u003e\u003cbr\u003e\u003cstrong\u003e\u003cspan\u003ePeptide Length:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e 16 Amino Acids\u003c\/span\u003e\u003cbr\u003e\u003cstrong\u003e\u003cspan\u003eMolecular Formula:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e C₁₀₁H₁₅₂N₂₈O₂₂S₂\u003c\/span\u003e\u003cbr\u003e\u003cstrong\u003e\u003cspan\u003eMolecular Weight:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e Approximately 2174.6 Da\u003c\/span\u003e\u003cbr\u003e\u003cstrong\u003e\u003cspan\u003eCAS Number:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e 1627580-64-6\u003c\/span\u003e\u003cbr\u003e\u003cstrong\u003e\u003cspan\u003eBrand:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e Helix Bio-Science\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3\u003e\u003cspan\u003eCurrent Scientific Research\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cspan\u003eMOTS-c has attracted growing attention following preclinical research demonstrating its involvement in metabolic regulation.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eA foundational study published in \u003c\/span\u003e\u003cem\u003e\u003cspan\u003eCell Metabolism\u003c\/span\u003e\u003c\/em\u003e\u003cspan\u003e in 2015 demonstrated that MOTS-c influenced AMPK-related metabolic pathways and improved measures of insulin resistance in experimental mouse models.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eFurther research published in \u003c\/span\u003e\u003cem\u003e\u003cspan\u003eNature Communications\u003c\/span\u003e\u003c\/em\u003e\u003cspan\u003e in 2021 investigated MOTS-c in relation to exercise, skeletal muscle metabolism and age-associated physical decline, reporting improvements in physical performance in mice.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eAdditional laboratory studies have explored its role in mitochondrial signalling, cellular stress responses and metabolic adaptation.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eHowever, controlled human clinical evidence remains insufficient to establish whether administering MOTS-c provides meaningful benefits for metabolism, exercise performance, weight management or longevity.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3\u003e\u003cspan\u003eImportant Research Disclaimer\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cspan\u003eMOTS-c is an investigational peptide and is not approved for general medical use, weight management, athletic performance enhancement or anti-ageing treatment.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eIts safety, effectiveness, appropriate administration and long-term effects in humans have not been adequately established.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eFor research use only. Not for human or animal consumption. Not intended to diagnose, treat, cure or prevent any disease.\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e","brand":"Helix Bio-Science","offers":[{"title":"Default Title","offer_id":60150554526041,"sku":null,"price":25.0,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1094\/3850\/1209\/files\/0B1E9D05-EFE1-4D5A-8A1D-4C2F5EE95557.png?v=1792910225","url":"https:\/\/helix-bioscience.com\/products\/mots-c","provider":"Helix Bio-Science","version":"1.0","type":"link"}