KPV – 10 mg

Advanced Anti-Inflammatory Research Peptide | Cellular & Immune Research

KPV (Lysine-Proline-Valine) is a synthetic tripeptide derived from the C-terminal amino acid sequence of alpha-melanocyte-stimulating hormone (α-MSH), a naturally occurring peptide involved in pigmentation, immune signalling and inflammatory regulation.

Comprising just three amino acids, KPV has attracted significant scientific interest for its potential influence on inflammatory signalling pathways, cellular responses and gastrointestinal tissue biology.

Unlike the full-length α-MSH peptide, KPV has demonstrated anti-inflammatory activity in experimental models without the same pigmentation-stimulating properties.

Its distinctive molecular structure has made it an emerging subject of research in immunology, gastroenterology, dermatology and cellular biology.

How Does KPV Work?

Preclinical research suggests that KPV may influence several biological pathways:

• Inflammatory Signalling: Investigated for its ability to inhibit NF-κB activation, a signalling pathway involved in regulating inflammatory responses.

• Cytokine Regulation: Laboratory studies have examined its effects on the production of pro-inflammatory signalling molecules.

• Gastrointestinal Research: Investigated in experimental models of intestinal inflammation, including inflammatory bowel disease-related pathways.

• Cellular Protection: Studied for its interactions with cellular responses associated with inflammatory stress and tissue injury.

• Skin & Dermatological Research: Explored for its potential influence on inflammatory processes involving skin cells and epidermal biology.

• Immune System Modulation: Investigated for its effects on signalling pathways associated with immune-cell activity.

• Peptide Transport Mechanisms: Research has examined how KPV interacts with the PepT1 transporter, which may facilitate cellular uptake in intestinal tissues.

Although experimental studies have reported interesting biological activity, these findings have not been established as clinical benefits in humans.

Key Research Areas

• Inflammatory signalling and NF-κB regulation

• Cytokine production and immune responses

• Gastrointestinal and intestinal tissue biology

• Skin inflammation and epidermal research

• Cellular protection and tissue responses

• Peptide transport and cellular uptake

• Immune modulation and inflammatory pathways

• Mucosal biology and barrier function

Product Information

Product: KPV (Lys-Pro-Val)
Strength: 10 mg
Classification: Synthetic Anti-Inflammatory Research Tripeptide
Peptide Length: 3 Amino Acids
Molecular Formula: C₁₆H₃₀N₄O₄
Molecular Weight: Approximately 342.43 Da
CAS Number: 67727-97-3
Brand: Helix Bio-Science

Current Scientific Research

KPV has demonstrated anti-inflammatory activity in laboratory and animal studies.

Research published in Gastroenterology in 2008 investigated KPV uptake through the PepT1 transporter and its influence on intestinal inflammation.

The study reported reductions in inflammatory signalling and experimental colitis severity in mouse models.

Additional research has investigated KPV's interactions with skin cells, inflammatory mediators and tissue-protection pathways.

However, published human clinical evidence remains insufficient to establish its safety or effectiveness for inflammatory conditions.

Important Research Disclaimer

KPV is an investigational peptide and is not approved for general medical use or the treatment of inflammatory, gastrointestinal or dermatological conditions.

Its safety, clinical effectiveness and long-term effects in humans have not been adequately established.

For research use only. Not for human or animal consumption. Not intended to diagnose, treat, cure or prevent any disease.