MOTS-c – 10 mg

Advanced Mitochondrial-Derived Peptide | Cellular Energy & Metabolic Research

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a naturally occurring 16-amino-acid peptide encoded within mitochondrial DNA.

Unlike many traditional peptides, MOTS-c originates from genetic information associated with mitochondria, the cellular structures responsible for much of the body's energy production.

MOTS-c has attracted significant scientific interest for its involvement in cellular energy regulation, glucose metabolism, insulin sensitivity and responses to metabolic stress.

Its distinctive biological activity has made it an emerging subject of research in mitochondrial science, metabolic health, exercise physiology and age-related cellular function.

How Does MOTS-c Work?

Preclinical research suggests that MOTS-c influences several important biological pathways:

• Mitochondrial & Cellular Energy Regulation: Investigated for its role in coordinating cellular metabolism and communication between mitochondria and the cell nucleus.

• AMPK Activation: Studied for its interactions with AMP-activated protein kinase (AMPK), a key regulator of cellular energy balance and metabolic signalling.

• Glucose Metabolism: Animal studies have examined its potential influence on glucose utilisation, insulin sensitivity and metabolic homeostasis.

• Exercise & Muscle Research: Investigated for its relationship with skeletal muscle metabolism, exercise-induced signalling and physical performance in animal models.

• Metabolic Stress Response: Research suggests MOTS-c may influence cellular adaptation to metabolic challenges through changes in gene expression.

• Ageing & Cellular Function: Explored in preclinical studies investigating age-associated changes in metabolic regulation and physical capacity.

• Oxidative Stress Pathways: Studied for its potential interactions with cellular antioxidant signalling and stress-response mechanisms.

Although these findings are promising areas of scientific investigation, they are predominantly based on laboratory and animal studies rather than established human clinical outcomes.

Key Research Areas

• Mitochondrial function and cellular metabolism

• AMPK activation and energy regulation

• Insulin sensitivity and glucose metabolism

• Skeletal muscle and exercise physiology

• Metabolic stress and cellular adaptation

• Age-associated metabolic changes

• Oxidative stress and antioxidant signalling

• Mitochondrial-to-nuclear communication

• Metabolic homeostasis and energy balance

Product Information

Product: MOTS-c
Strength: 10 mg
Classification: Mitochondrial-Derived Peptide
Peptide Length: 16 Amino Acids
Molecular Formula: C₁₀₁H₁₅₂N₂₈O₂₂S₂
Molecular Weight: Approximately 2174.6 Da
CAS Number: 1627580-64-6
Brand: Helix Bio-Science

Current Scientific Research

MOTS-c has attracted growing attention following preclinical research demonstrating its involvement in metabolic regulation.

A foundational study published in Cell Metabolism in 2015 demonstrated that MOTS-c influenced AMPK-related metabolic pathways and improved measures of insulin resistance in experimental mouse models.

Further research published in Nature Communications in 2021 investigated MOTS-c in relation to exercise, skeletal muscle metabolism and age-associated physical decline, reporting improvements in physical performance in mice.

Additional laboratory studies have explored its role in mitochondrial signalling, cellular stress responses and metabolic adaptation.

However, controlled human clinical evidence remains insufficient to establish whether administering MOTS-c provides meaningful benefits for metabolism, exercise performance, weight management or longevity.

Important Research Disclaimer

MOTS-c is an investigational peptide and is not approved for general medical use, weight management, athletic performance enhancement or anti-ageing treatment.

Its safety, effectiveness, appropriate administration and long-term effects in humans have not been adequately established.

For research use only. Not for human or animal consumption. Not intended to diagnose, treat, cure or prevent any disease.